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Contraindicated (two)phenobarbital will decrease the level or influence of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Monitor Closely (1)phenobarbital will reduce the level or effect of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. If coadministration with a CYP3A4 induce
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